Human rights have surged to the forefront of the debate about what will succeed the Millennium Development Goals in 2015. As human rights and social justice organizations worldwide, we feel compelled to lay out some of the baseline implications of embedding human rights into the core of the sustainable development agenda this time around. At its essence, a post- 2015 framework anchored in human rights moves from a model of charity to one of justice, based on the inherent dignity of people as human rights-holders, domestic governments as primary duty-bearers, and all development actors sharing common but differentiated responsibilities. Accordingly, the post-2015 framework should be designed as a tool to empower and enable people—individually and collectively—to monitor and hold their governments, other governments, businesses, international institutions and other development actors to account for their conduct as it affects people’s lives within and beyond borders. A sustainable development framework founded in human rights can serve as an instrument for people and countries to help unseat the structural obstacles to sustainable, inclusive and just development, prevent conflict and stimulate implementation and enforcement of all human rights—civil, political, economic, social and cultural rights, the right to development, and to a healthy environment.